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Zymeworks Announces Strategic Initiative to Optimize Value of Licensed Products

Zymeworks Inc. (ZYME) | November 18, 2025

By Laura Young

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Zymeworks Inc. announced a strategic initiative to maximize the value of licensed products and healthcare assets.

The initiative aims to generate sustainable value for shareholders through a combination of internal innovation, licensing, and strategic acquisitions.

This decision follows positive results from the Phase 3 HERIZON-GEA-01 trial for zanidatamab in first-line gastroesophageal adenocarcinoma.

Potential Near-Term Milestone Payments

Eligible to receive up to $440.0 million in milestone payments upon global regulatory approvals for Ziihera in gastroesophageal adenocarcinoma.

Share Repurchase Plan

Authorized a new share repurchase plan of $125.0 million to enhance shareholder value.

Revenue Generation Strategy

Expect substantial royalty and milestone revenues from commercialization of Ziihera and strategic partnerships.

  • The strategic initiative aims to optimize long-term revenue streams by leveraging current licensed products and promising R&D partnerships.
  • Zymeworks anticipates significant cash flows from regulatory approvals and commercialization of Ziihera and pasritamig, driving future growth and profitability.

Zymeworks' shift towards a royalty-driven organization with a focus on in-house R&D is expected to deliver sustained value for shareholders and fuel innovation in the biotechnology sector.