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Rein Therapeutics Wins U.K. Approval for Phase 2 Clinical Trial of LTI-03

Rein Therapeutics (RNTX) | Aug. 19, 2025

By Liam Parker

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Rein Therapeutics announced the authorization to initiate the Phase 2 clinical trial of LTI-03 for idiopathic pulmonary fibrosis.

LTI-03 is a first-in-class therapy targeting fibrosis while preserving lung tissue regeneration.

The trial aims to enroll up to 120 patients worldwide with primary focus on safety and tolerability.

Phase 2 Trial Approval

UK MHRA authorized Rein Therapeutics to begin the Phase 2 trial of LTI-03 for IPF.

LTI-03 Potential Breakthrough

LTI-03 could revolutionize pulmonary fibrosis treatment by targeting fibrosis directly.

Patient Recruitment Progress

Rein is actively engaging with clinical sites to recruit patients for the RENEW trial.

  • The Phase 2 trial marks a significant advancement in the development of potential treatments for IPF.
  • Successful outcomes from this trial could lead to improved options for patients suffering from the debilitating effects of pulmonary fibrosis.

The approval for the Phase 2 trial of LTI-03 signifies a promising step towards addressing unmet medical needs in pulmonary fibrosis treatment.