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Pfizer Reaffirms Full-Year 2025 EPS Guidance and Provides Full-Year 2026 Guidance

Pfizer Inc. (PFE) | December 16, 2025

By Wendy Roberts

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Pfizer reaffirmed its full-year 2025 adjusted diluted EPS guidance and revised the revenue guidance to approximately $62.0 billion.

For full-year 2026, Pfizer provided revenue guidance ranging from $59.5 to $62.5 billion.

The company expects operational revenue growth of approximately 4% year-over-year in 2026 excluding COVID-19 and loss of exclusivity products.

Full-Year 2025 Guidance Reaffirmed

Pfizer reaffirmed its full-year 2025 adjusted diluted EPS guidance.

Revenue Guidance Revision

The full-year 2025 revenue guidance was revised to around $62.0 billion.

Full-Year 2026 Guidance

Pfizer provided full-year 2026 revenue guidance and adjusted diluted EPS expectations.

  • Pfizer's strategic investments in pipeline and acquired assets in 2026 aim to fuel long-term growth.
  • The company anticipates revenue impact from COVID-19 products and loss of exclusivity products in 2026.
  • By focusing on key therapeutic areas and prioritizing development programs, Pfizer aims to optimize SI&A and R&D expenses for 2026.

Pfizer's financial guidance highlights its commitment to sustainable growth and value creation for shareholders in 2026.