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Ixo-vec Gene Therapy for nAMD: Clinical Progress from the LUNA Phase 2 Trial

Adverum (ADVM) | December 2025

By Tina Carter

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Adverum presents promising clinical progress on Ixo-vec gene therapy for nAMD in the LUNA Phase 2 Trial.

Potential benefits include best-in-class product profile and favorable safety profile.

Ixo-vec aims to address the unmet needs of patients with wet AMD.

Treatment Potential

Ixo-vec shows potential as a one-and-done IVT injection for wet AMD patients.

Reduced Treatment Burden

Promising results indicate sustainable long-term disease control with reduced treatment burden.

Transformational Therapy

Ixo-vec gene therapy has the potential to transform the treatment paradigm for wet AMD patients.

  • Adverum's Ixo-vec gene therapy demonstrates significant potential for the treatment of wet AMD.
  • The therapy aims to provide robust disease control with reduced treatment burden, offering hope to patients.
  • Promising clinical data suggest a positive impact on quality of life for individuals with nAMD.

Adverum's progress with Ixo-vec gene therapy marks a significant step towards addressing the challenges faced by patients with wet AMD. The clinical data and potential benefits highlight a promising future for this innovative approach in ophthalmology.