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Repare Therapeutics Announces Acquisition of Pol heta ATPase Inhibitor by Gilead Sciences

Repare Therapeutics Inc. (RPTX) | December 24, 2025

By Hannah Lewis

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Repare Therapeutics announces the acquisition of RP-3467, a Pol heta ATPase inhibitor, by Gilead Sciences for up to $30 million in total consideration.

The agreement includes a $25 million upfront payment and an additional $5 million payment upon completion of specified technology transfer activities.

The acquisition strengthens Repare's position in precision oncology and marks a significant milestone for the Company.

Strategic Acquisition

Gilead Sciences acquiring RP-3467 enhances its oncology research and development capabilities.

Total Consideration

Repare to receive up to $30 million, boosting the Company's financial position.

Portfolio Transaction

The Gilead Agreement is Repare's third and most significant portfolio transaction of the year.

  • The upfront payment from Gilead has increased Repare's cash balance and revised the estimated cash payment per share for shareholders.
  • RP-3467, a potent Pol heta ATPase inhibitor, holds promise in treating various cancers, including ovarian, breast, and prostate cancers.

With the acquisition of RP-3467 by Gilead Sciences, Repare Therapeutics is poised for further growth in the precision oncology sector.