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MBX Biosciences Doses First Participant in Phase 1 Trial of MBX 4291 for the Treatment of Obesity

MBX Biosciences (MBX) | September 4, 2025

By Liam Parker

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MBX Biosciences, Inc. has dosed the first participant in its Phase 1 trial of MBX 4291, a Precision Endocrine Peptide™ candidate for treating obesity.

MBX 4291 aims to offer improved weight loss and tolerability with once-monthly administration, potentially surpassing current treatment options.

The Phase 1 trial will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of MBX 4291 in adult participants with obesity.

Significant Milestone in Clinical Trial

Initiation of the first clinical trial for obesity, showcasing progress in addressing a global health concern.

Potential Benefits of MBX 4291

Offers convenient once-monthly administration, improved weight loss efficacy, and enhanced gastrointestinal tolerance compared to existing treatments.

Upcoming Topline Results

Anticipated topline results for the Phase 1 trial expected in 2027, signaling future insights into MBX 4291's effectiveness.

  • MBX 4291's design as a novel precision peptide therapy signifies a shift towards advanced treatment options for endocrine and metabolic disorders.
  • Preclinical data supporting MBX 4291's efficacy echo promising outcomes, positioning it as a potential game-changer in obesity treatment.

With the dosing of the first participant in the Phase 1 trial, MBX Biosciences is on track to revolutionize obesity treatment with MBX 4291. The company's commitment to innovation and addressing healthcare challenges is evident in its precision peptide platform.