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Ionis Pharmaceuticals Files Complaint Against Arrowhead Pharmaceuticals for Patent Infringement

Ionis Pharmaceuticals, Inc. (IONIS) | 09/11/25

By Noah Edwards

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Ionis Pharmaceuticals, Inc. filed a complaint against Arrowhead Pharmaceuticals, Inc. addressing the infringement of U.S. Patent No. 9,593,333.

Ionis's complaint highlights Arrowhead's infringement in relation to the treatment of hypertriglyceridemia, a serious health condition.

The complaint discusses Ionis's innovative approach using antisense oligonucleotides to target ApoCIII messenger RNA for developing potential treatments.

Innovative Treatment Approach

Ionis used antisense oligonucleotides to target ApoCIII mRNA, inhibiting the synthesis of the ApoCIII protein for potential medical benefits.

Success in Clinical Trials

Ionis demonstrated the efficacy of ApoCIII inhibition in treating hypertriglyceridemia, achieving remarkable results in clinical trials.

Patent Recognition

Ionis was granted the '333 patent for its groundbreaking invention, recognizing the novel treatment for LPL-deficient individuals.

  • Ionis's development of volanesorsen and olezarsen showcases significant advancements in treating hypertriglyceridemia and related conditions.
  • The successful clinical trials and patent recognition signify Ionis's leadership in developing innovative therapeutic solutions.

The complaint filed by Ionis Pharmaceuticals highlights the company's dedication to pioneering treatments for severe health conditions through innovative approaches and successful clinical outcomes. It underlines Ionis's commitment to advancing healthcare solutions for patients in need.