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Atossa Therapeutics Receives FDA 'Study May Proceed' Letter for (Z)-Endoxifen Investigational New Drug Application for Metastatic Breast Cancer

Atossa Therapeutics (ATOS) | January 6, 2026

By Tina Carter

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Atossa Therapeutics received an FDA 'Study May Proceed' letter for their study in metastatic breast cancer for (Z)-Endoxifen.

The Company believes that (Z)-Endoxifen may offer a new tool in treating metastatic ER+/HER2- Breast Cancer.

The FDA's review of Atossa's application marks an important regulatory milestone.

Regulatory Milestone Achieved

FDA issued a 'Study May Proceed' letter for Atossa's (Z)-Endoxifen study in metastatic breast cancer.

Potential Treatment Expansion

Belief in expanding the use of (Z)-Endoxifen for treating resistant tumors in metastatic breast cancer.

Unique Pharmacology

Atossa's oral formulation of (Z)-Endoxifen shows distinct pharmacology from tamoxifen, targeting ER and PKC.

  • The issuance of the 'Study May Proceed' letter signifies progress in advancing Atossa's investigational new drug application.
  • Atossa's (Z)-Endoxifen program holds promise for offering new therapeutic options in oncology and rare diseases.

Atossa Therapeutics is on track to explore the potential of (Z)-Endoxifen in treating metastatic breast cancer, with a focus on developing innovative medicines for unmet medical needs.