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Akebia Establishes Rare Kidney Disease Pipeline with Acquisition and Initiates Trials

Akebia Therapeutics, Inc. (AKBA) | December 1, 2025

By Quinn Adams

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Akebia Therapeutics announced the establishment of a rare kidney disease pipeline.

The pipeline includes ADX-097, a complement inhibitor, and praliciguat, an sGC stimulator.

Akebia acquired ADX-097 from Q32 Bio and initiated a Phase 2 trial for praliciguat in FSGS.

Pipeline Introduction

Akebia's rare kidney disease pipeline comprises ADX-097 and praliciguat to address complement-mediated rare kidney diseases.

Complement Inhibition Mechanism

ADX-097 functions by specifically binding to complement proteins, halting inflammatory responses and cell destruction.

Financial Agreement

Akebia acquired ADX-097 from Q32 Bio in an Asset Purchase Agreement for $7.0 million upfront and potential additional payments.

  • Akebia's pipeline aims to provide innovative treatments for rare kidney diseases.
  • The acquisition of ADX-097 and initiation of praliciguat trials mark significant progress in Akebia's development strategy.

Akebia's focus on rare kidney diseases through ADX-097 and praliciguat showcases its commitment to advancing kidney disease treatments. The company's strategic acquisitions and trial initiations signal promising developments for the future of kidney disease therapies.